منابع مشابه
(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals.
The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons. Although the neurotoxic effects of MDMA in animals are widely accepted, the r...
متن کاملAnesthetic-induced developmental neurotoxicity: causes, prospective studies and possible interventions
Mechanism of AIDN: The agents lead to damage in the hippocampus and amygdala which leads to learning and memory disturbances subsequently. The γ-aminobutyric acid (GABA)-ergic and glutaminergic neurons have been found to undergo apoptosis due to exposure. Experimental studies have shown that nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation occurs due to inhalational anesth...
متن کاملManganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates
BACKGROUND Exposure to excess levels of the essential trace element manganese produces cognitive, psychiatric, and motor abnormalities. The understanding of Mn neurotoxicology is heavily governed by pathologic and neurochemical observations derived from rodent studies that often employ acute Mn exposures. The comparatively sparse studies incorporating in vivo neuroimaging in nonhuman primates p...
متن کاملMethotrexate neurotoxicity: in vitro studies using cerebellar explants from rats.
The mechanism of methotrexate (MTX)-induced neurotoxicity was investigated using cerebellar explant cultures from fetal rats. After 3 weeks of growth, myelinated cultures were treated with MTX at 1 microM, lysolecithin at 1 mg/dl, or unaltered nutrient medium. Myelin sheaths devoid of axons were observed by histological and electron microscopic preparations after 2 weeks of MTX exposure. After ...
متن کاملFluoroGold-Labeled Organotypic Retinal Explant Culture for Neurotoxicity Screening Studies
Preclinical toxicity screening of the new retinal compounds is an absolute requirement in the pathway of further drug development. Since retinal neuron cultivation and in vivo studies are relatively expensive and time consuming, we aimed to create a fast and reproducible ex vivo system for retinal toxicity screening. For this purpose, we used rat retinal explant culture that was retrogradely la...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2008
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.131.462